Rapid and massive virus specific plasmablast responses during acute 1 dengue virus infection in humans 2 Running title :
نویسندگان
چکیده
Running title: Plasmablast responses to dengue infection 3 Jens Wrammert, Nattawat Onlamoon, Rama S. Akondy, Guey C. Perng, 4 Korakot Polsrila, Anmol Chandele, Marcin Kwissa, Bali Pulendran, Patrick 5 Wilson, Orasri Wittawatmongkol, Sutee Yoksan, Nasikarn Angkasekwinai, 6 Kovit Pattanapanyasat, Kulkanya Chokephaibulkit, Rafi Ahmed 7 8 Emory Vaccine Center, School of Medicine, Emory University, Atlanta, USA. 9 Department of Microbiology and Immunology, School of Medicine, Emory 10 University, Atlanta, USA. Office for Research and Development, Faculty of 11 Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. Department of 12
منابع مشابه
Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients.
Dengue is a globally expanding disease caused by infection with dengue virus (DENV) that ranges from febrile illness to acute disease with serious complications. Secondary infection predisposes individuals to more severe disease, and B lymphocytes may play a role in this phenomenon through production of Ab that enhance infection. To better define the acute B cell response during dengue, we anal...
متن کاملDominant Cross-Reactive B Cell Response during Secondary Acute Dengue Virus Infection in Humans
The four serotypes of dengue virus (DENV) cause dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Severe disease has been associated with heterotypic secondary DENV infection, mediated by cross-reactive antibodies (Abs) and/or cross-reactive T cells. The role of cross-reactive immunity in mediating enhanced disease versus cross-protection against secondary heteroty...
متن کاملDengue Virus Activates Polyreactive, Natural IgG B Cells after Primary and Secondary Infection
BACKGROUND Dengue virus is transmitted by mosquitoes and has four serotypes. Cross-protection to other serotypes lasting for a few months is observed following infection with one serotype. There is evidence that low-affinity T and/or B cells from primary infections contribute to the severe syndromes often associated with secondary dengue infections. such pronounced immune-mediated enhancement s...
متن کاملZika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors.
Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV. We have tracked the evolution of ZIKV-induced B cell responses in three DENV-experienced donors. The acute antibody (plasmablast) responses were characterized by relatively high somatic hypermutation and a bias toward DENV binding and n...
متن کاملB Cell Responses during Secondary Dengue Virus Infection Are Dominated by Highly Cross-Reactive, Memory-Derived Plasmablasts.
UNLABELLED Dengue virus (DENV) infection results in the production of both type-specific and cross-neutralizing antibodies. While immunity to the infecting serotype is long-lived, heterotypic immunity wanes a few months after infection. Epidemiological studies link secondary heterotypic infections with more severe symptoms, and cross-reactive, poorly neutralizing antibodies have been implicated...
متن کامل